826 GENETIC HETEROGENEITY IN ARTHROGRYPOSIS (MULTIPLE CONGENITAL CONTRACTURES)

Arthrogryposis Multiplex Congenita: Multiple Congenital Joint Contractures

Arthrogryposis multiplex congenita (AMC) is a syndrome characterized by nonprogressive multiple congenital joint contractures. The etiology of disease is multifactorial; it is most commonly suspected from absent fetal movements and genetic defects. AMC affects mainly limbs; also it might present with other organs involvement. It is crucial that the diagnosis of AMC should be kept in mind by mus...

Arthrogryposis (multiple congenital contractures): diagnostic approach to etiology, classification, genetics, and general principles.

Arthrogryposis has been the term used to describe multiple congenital contractures for over a century. It is a descriptive term and present in over 400 specific conditions. Responsible gene abnormalities have been found for more than 150 specific types of arthrogryposis. Decreased fetal movement is present in all affected individuals which leads to a variety of secondary deformations. Decreased...

Aortic aneurysm in three siblings with multiple congenital contractures.

Congenital arthrogryposis associated with musculoskeletal defects in three newborn goats

Arthrogryposis as a congenital malformation that refers to the fixed flexion of one or more joints as a result of stiffness or limited movements of multiple joints, change of posture and limb function due to permanent contracture of joints and wasting of muscles that usually occur at early stage of gestation. This report describes congenital arthrogryposis associated with musculoskeletal defect...

Arthrogryposis accompanying congenital spinal-type muscular atrophy.

Arthrogryposis is a congenital condition in which multiple skeletal deformities of the extremities and spine are caused by fibrosis and contractures of skeletal muscles accompanying a neurogenic atrophy (Brandt, 1947; Kanof, Aronson, and Volk, 1956; Bargeton, Nezelof, Guran, and Job, 1961; Vestermark, 1966) or a primary myopathy (Thamdrup, 1955; Banker, Victor, and Adams, 1957) acquired in uter...